Helle received her veterinary degree from University of Copenhagen, Denmark, in 2010. She worked at Copenhagen Zoo from 2010-2011 before volunteering as a civil veterinarian for World Vets on two humanitarian missions with the US Military in 2011 and 2012. In April 2013, she completed the Educational Commission for Foreign Veterinary Graduates (ECFVG) certification program and the North American Veterinary Licensing Examination (NAVLE). Helle then provided veterinary disaster relief for World Vets in the Philippines after the typhoon Haiyan in 2013. She did a small animal rotating internship at the 404 Veterinary Emergency and Referral Hospital in Ontario, Canada, in 2014-2015 and completed her 3-year residency in Wildlife Population Health and MVetMed at the Institute of Zoology, Zoological Society of London, and the Royal Veterinary College, University of London, in 2018. Helle became an EBVS® European Veterinary Specialist in Wildlife Population Health in April 2019. From 2019 to 2023, she conducted her PhD project entitled "Exposure and impacts of lead (Pb) in Scandinavian brown bears (Ursus arctos)" at Nottingham Trent University, United Kingdom. In 2023, Helle became the first Danish Veterinary Specialist in Wildlife Population Health, and in the same year she worked as a Border Control Post Veterinarian in Copenhagen, Denmark. She is currently an Assistant Professor at the Faculty of Health and Medical Sciences, University of Copenhagen, Denmark. She was a member of ECZM's Communication and Outreach Committee from 2020 to 2023 and has since September 2023 been the ECZM Wildlife Population Health Specialty Chair.