Senior Investigative & Toxicologic Pathologist Investigative Pathology - Development of pharmacodynamic and predictive tissue biomarkers (IHC, in situ hybridization) - Characterization of animal models for a better translation to human diseases - Selection of cancers of interest based on biomarker expression - Evaluation of mode of actions of drug candidates (preclinical models & exploratory clinical trials) Toxicologic pathology - Early toxicity evaluation for better assessment of efficacy/safety ratio in pharmacology studies - Evaluation of mechanism of toxicity - Predictive toxicology with tissue target distribution in normal human tissues - Peer Reviews and pathology / toxicology report reviews - Derisking safety issues, review of regulatory documents (IB, IND, responses to authorities…)